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KMID : 1033820000010010051
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Journal of Artificial Heart Research
2000 Volume.1 No. 1 p.51 ~ p.64
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Computer simulation of the circulatory physiology for a beta-blocker combined therapy in the BVAD Implanted patient
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Jo Yung-Ho
Min Byoung-Goo
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Abstract
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The purpose of this study is to predict the cardiovascular hemodynamic effect of the moving actuator pump Bi-ventricular Assist Device (BVAD) and the β blocker therapy in a heart failure patient. We developed the numerical model of the BVAD using several coupled nonlinear differential equations and integrated the circulatory physiology model called QCP2 that was developed by Tom Coleman after modification of QCP2 source files to interact the BVAD model. The BVAD model include two blood sacs and variable volume, energy transmission part with gear and motor, which are enclosed by the chamber housing. The therapy for the simulation of a heart failure patient are classified by followings ; BVAD implantation, β blocker administration, combined therapy with β blocker and BVAD, and they are compared with control which has no treatment. β blocker therapy showed the decrease in the work load of the patient’s heart with the decrease in heart rate, cardiac output, arterial blood pressure. In BVAD implantation, it showed improvement of the hemodynamic values as well as the decrease in the work load of the patient’s heart. Combined therapy with β blocker and BVAD showed that mean arterial pressure is decreased and cardiac index is improved, as compared with the BVAD implantation therapy. In conclusion, Combined therapy with β blocker and BVAD is preferred as a therapy for a heart failure patient because the BVAD could improve patient hemodynamic condition and this could help to use drug therapy like a β blocker with safety margin.
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KEYWORD
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computer simulation, bi-ventricular assist device, β blocker
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